How to Take KALYDECO®

Take KALYDECO every 12 hours or as directed by your healthcare provider

  • Taking KALYDECO every 12 hours helps keep enough medicine in the body
  • Remember, taking KALYDECO every 12 hours is not the same as taking it twice a day
  • Your dose may be different—your healthcare provider will tell you how much KALYDECO to take and when to take it

Always take KALYDECO with fat-containing food

  • Fat-containing food helps the body absorb KALYDECO better 

    See examples of fat-containing foods.
     
  • Avoid foods or drinks that contain grapefruit, as these may affect the amount of KALYDECO in the body

Take KALYDECO, plus all your other cystic fibrosis (CF) therapies, exactly as your healthcare provider tells you to take them

  • Be sure to talk to your healthcare provider before starting, changing, or stopping any CF therapies or other medications, including prescription and non-prescription medicines, vitamins, and herbal supplements

Before you start taking KALYDECO, be sure KALYDECO is right for you.

To learn how to take KALYDECO oral granules or tablets, from how they're supplied to step-by-step instructions, choose one below.

 

How to take KALYDECO oral granules

How to take KALYDECO tablets

How to take KALYDECO oral granules

KALYDECO is supplied as oral granules for children with CF age 4 months to less than 6 years old

Meet Grant and learn how to take KALYDECO oral granules

 

 

How KALYDECO oral granules are packaged

KALYDECO oral granules guide

 

Each box of KALYDECO oral granules contains 4 wallet cards for a total of 56 unit dose packets—or a 28-day supply of granules.

Each wallet card contains 14 doses. This is enough for a week based on dosing twice a day every 12 hours.

KALYDECO granules are available in 3 different strengths (25-mg, 50-mg and 75-mg packets). Your child's doctor will prescribe the appropriate dose based on your child's weight.

KALYDECO oral granules recommended doses

IF YOUR CHILD IS: AND WEIGHS: THE RECOMMENDED DOSE IS:
4 months to less than 6 months old 11 pounds or more
(5 kg or more)
One 25-mg packet every 12 hours
Total daily dose: 50 mg
6 months to less than 6 years old 11 pounds to less than 15 pounds
(5 kg to <7 kg)
One 25-mg packet every 12 hours
Total daily dose: 50 mg
15 pounds to less than 31 pounds
(7 kg to <15 kg)
One 50-mg packet every 12 hours
Total daily dose: 100 mg
31 pounds or more
(14 kg or more)
One 75-mg packet every 12 hours
Total daily dose: 150 mg
IF YOUR CHILD IS:
4 months to less than 6 months old 6 months to less than 6 years old
AND WEIGHS:
11 pounds or more
(5 kg or more)
11 pounds to less than 15 pounds
(5 kg to <7 kg)
15 pounds to less than 31 pounds
(7 kg to <15 kg)
31 pounds or more
(14 kg or more)
THE RECOMMENDED DOSE IS: 
One 25-mg packet every 12 hours
Total daily dose: 50 mg
One 25-mg packet every 12 hours
Total daily dose: 50 mg
One 50-mg packet every 12 hours
Total daily dose: 100 mg
One 75-mg packet every 12 hours
Total daily dose: 150 mg

How often should my child take KALYDECO? 

  • Take KALYDECO every 12 hours with fat-containing food unless otherwise directed by your healthcare provider
  • Your child's dose may be different. Your child should take KALYDECO exactly as his or her doctor tells you he or she should take it

How to give your child KALYDECO oral granules

Step 1: Preparation
  • Hold 1 packet of KALYDECO oral granules with the cut line on top
  • Shake the packet gently to settle the KALYDECO granules
  • Tear or cut the packet open along the cut line
  • Carefully pour all of the KALYDECO granules into 1 teaspoon (5 mL) of age-appropriate soft food or liquid and mix. Food should be at or below room temperature.

    Here are examples of foods and liquids you can mix KALYDECO granules into. Remember, every child is different, so be sure to talk to your healthcare provider about what the best options are for your child.
    • Breast milk

    • Infant formula

    • Puréed fruits or vegetables

    • Yogurt

    • Applesauce

    • Water

    • Milk

    • Juice

  • Then, mix the granules with the 1 teaspoon of food or liquid
Step 2: Administration
  • Within 1 hour of mixing, give KALYDECO to your child
  • Make sure the entire medicine mixture is taken
Step 3: Fat-containing food before or after the dose

Always take KALYDECO with fat-containing food

  • Make sure to give your child age-appropriate fat-containing food just before or just after the dose of KALYDECO granules. This helps the body absorb KALYDECO better
  • Here are suggestions for fat-containing foods to give your child:
    • Breast milk

    • Infant formula

    • Whole milk

    • Whole-milk yogurt

    • Eggs

    • Whole-milk cheese

    • Butter

    • Peanut butter

    • Cheese pizza

  • Talk to your healthcare provider about fat-containing foods appropriate for your child when taking KALYDECO granules

 

What if your child misses a dose of KALYDECO?

If your child misses a dose of KALYDECO and it is within 6 hours of when he or she usually takes it, have your child take the dose of KALYDECO as prescribed with fat-containing food as soon as possible.

If your child misses a dose and it is more than 6 hours after the time he or she usually takes it, have your child skip that dose only and take the next dose with fat-containing food when he or she usually takes it. Do not take 2 doses at the same time to make up for a missed dose.

How to take KALYDECO tablets

KALYDECO is supplied as tablets (150 mg) for people 6 years and older.

  • Each KALYDECO box contains 4 individual blister cards. Each blister card contains 14 pills—7 morning doses and 7 evening doses
KALYDECO tablets
Not actual size.

How often should you take KALYDECO tablets? 

  • Take KALYDECO every 12 hours with fat-containing food unless otherwise directed by your healthcare provider
  • Your dose may be different. Take KALYDECO exactly as your doctor tells you to take it

What if you miss a dose of KALYDECO?

If you miss a dose of KALYDECO and it is within 6 hours of when you usually take it, take the dose of KALYDECO as prescribed with fat-containing food as soon as possible.

If you miss a dose and it is more than 6 hours after the time you usually take it, skip that dose only and take the next dose with fat-containing food when you usually take it. Do not take 2 doses at the same time to make up for a missed dose.