How KALYDECO® (ivacaftor) Works

KALYDECO affects gating of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. KALYDECO is used in patients with CF age 2 years and older who have at least one mutation in their CF gene that is responsive to KALYDECO.

About Gating Defects Callout

In patients with a mutation in their CF gene that is responsive to KALYDECO, KALYDECO helps the “gates” open more often, allowing more chloride ions to move into and out of the cells. The movement of chloride ions may help keep a balance of salt and water in the lungs.

*The R117H mutation causes both a gating and a conductance defect. KALYDECO only works to improve CFTR protein gating, so it has no effect on the R117H mutation conductance defect.

What is known about how KALYDECO works was learned from studies conducted in a lab. Keep in mind that results from laboratory studies do not always match how these medicines work in a person. If you have any questions about your treatment, please speak with your doctor.

Understanding KALYDECO: A Video Series

Watch to learn about KALYDECO, including who it’s for, how it works, and how it’s taken.

This video series is intended to help you understand more about CF and treatment with KALYDECO. However, it should not replace discussions with your healthcare providers. Talk with your doctor if you have any questions about KALYDECO or CF.

Watch the complete video series below.

What is KALYDECO® (ivacaftor)?

Cystic Fibrosis (CF) and Your Genes

Important Safety Information

How Does KALYDECO® (ivacaftor) Work?

Taking KALYDECO® (ivacaftor)

What is KALYDECO® (ivacaftor)?

KALYDECO is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients age 2 years and older who have at least one mutation in their CF gene that is responsive to KALYDECO.

Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if KALYDECO is safe and effective in children under 2 years of age.

Important Safety Information

Who should not take KALYDECO?

Do not take KALYDECO if you take certain medicines or herbal supplements such as: the antibiotics rifampin (Rifamate®, Rifater®) or rifabutin (Mycobutin®); seizure medications such as phenobarbital, carbamazepine (Tegretol®, Carbatrol®, Equetro®) or phenytoin (Dilantin®, Phenytek®); or St. John’s wort.

Talk to your doctor before taking KALYDECO if you take any of these medicines or supplements.