How KALYDECO® Works
KALYDECO affects gating of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. KALYDECO is used in patients age 2 years and older who have at least one mutation in their CF gene that is responsive to KALYDECO.
In patients with a mutation in their CF gene that is responsive to KALYDECO, KALYDECO works to help the "gates" stay open longer, allowing more chloride ions to move into and out of the cells. The movement of chloride ions may help keep a balance of salt and water in the lungs. KALYDECO does not increase the number of CFTR proteins at the cell surface.
What is known about how KALYDECO works was learned from studies conducted in a lab. Keep in mind that results from laboratory studies do not always match how these medicines work in a person. If you have any questions about your treatment, please speak with your healthcare provider.
Understanding KALYDECO: A Video Series
Watch to learn about KALYDECO, including who it's for, how it works, and how it's taken.
This video series is intended to help you understand more about CF and treatment with KALYDECO. However, it should not replace discussions with your healthcare providers. Talk with your doctor if you have any questions about KALYDECO or CF.
What is KALYDECO® (ivacaftor)?
KALYDECO is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients age 12 months and older who have at least one mutation in their CF gene that is responsive to KALYDECO.
Talk to your doctor to learn if you have an indicated CF gene mutation.
It is not known if KALYDECO is safe and effective in children under 12 months of age.
Important Safety Information
Who should not take KALYDECO?
Do not take KALYDECO if you take certain medicines or herbal supplements, such as:
- the antibiotics rifampin (Rifamate®, Rifater®) or rifabutin (Mycobutin®)
- seizure medicines such as: phenobarbital, carbamazepine (Tegretol®, Carbatrol®, and Equetro®), or phenytoin (Dilantin®, Phenytek®)
- St. John’s wort (Hypericum perforatum)
Talk to your doctor before taking KALYDECO if you take any of the medicines or supplements listed above.