How to Take KALYDECO® (ivacaftor)

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Take KALYDECO every 12 hours or as directed by your healthcare provider

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  • Taking KALYDECO every 12 hours helps keep enough medicine in the body
  • Remember, taking KALYDECO every 12 hours is not the same as taking it twice a day
  • Your dose may be different—your healthcare provider will tell you how much KALYDECO to take and when to take it
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  • Avoid foods or drinks that contain grapefruit or Seville oranges, as these may affect the amount of KALYDECO in the body
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Always take KALYDECO with fat-containing food

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Fat-containing food helps the body absorb KALYDECO better. Click here for examples of fat-containing food.

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Take KALYDECO, plus all your other CF therapies, exactly as your healthcare provider tells you to take them

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Be sure to talk to your healthcare provider before starting, changing, or stopping any CF therapies or other medications, including prescription and non-prescription medicines, vitamins, and herbal supplements.

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Choose tablets or oral granules.

To learn how to take KALYDECO tablets or oral granules, from how it's supplied to step-by-step instructions, choose one below.

KALYDECO is supplied as tablets (150 mg) for people 6 years and older.

Tablets depicted here are not actual size.

How should you take KALYDECO Tablets?

  • Take KALYDECO exactly as your doctor tells you to take it
  • Take your doses of KALYDECO 12 hours apart
  • Each KALYDECO box contains 4 individual blister cards. Each blister card contains 14 pills—7 morning doses and 7 evening doses

What if you miss a dose of KALYDECO?

If you miss a dose of KALYDECO and it is within 6 hours of when you usually take it, take the dose of KALYDECO as prescribed with fat-containing food as soon as possible.

If you miss a dose and it is more than 6 hours after the time you usually take it, skip that dose only and take the next dose with fat-containing food when you usually take it. Do not take 2 doses at the same time to make up for a missed dose.

KALYDECO is supplied as oral granules for children with CF age 2 to less than 6 years

Granules_Box_Packet_and_GrantGranules depicted here are not actual size.

Each box of KALYDECO oral granules contains 4 wallet cards for a total of 56 unit dose packets—or a 28-day supply of granules.

Each wallet card contains 14 doses. This is enough for a week based on dosing twice a day every 12 hours.

KALYDECO granules are available in 2 different formulations (50-mg and 75-mg packets). Your child's doctor will prescribe the appropriate dose based on your child’s weight.

How should my child take KALYDECO?

  • Your child should take KALYDECO exactly as his or her doctor tells you he or she should take it
  • Your child should take his or her doses of KALYDECO 12 hours apart

Meet Grant and learn how to take KALYDECO oral granules

The following video shows how to prepare and administer KALYDECO granules.

How to Take KALYDECO Oral Granules

How to take KALYDECO oral granules

Step 1

Carefully pour all of the KALYDECO granules in the packet into 1 teaspoon (5 mL) of soft food or liquid, and mix.

Examples of soft foods or liquids that you can mix with KALYDECO granules include:

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  • Applesauce, or other puréed fruits or vegetables
  • Yogurt
or
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  • Water
  • Milk
  • Juice

Food or liquid should be at or below room temperature. After mixing, give KALYDECO within 1 hour. Make sure all of the medicine mixture is taken.

Step 2

Give your child fat-containing food just before or after the dose of KALYDECO granules. Click here to see some suggestions.

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Examples of fat-containing foods include:

  • Eggs
  • Peanut butter
  • Whole-milk cheese pizza
  • Whole milk, cheese, or whole-milk yogurt

What if your child misses a dose of KALYDECO?

If your child misses a dose of KALYDECO and it is within 6 hours of when he or she usually takes it, have your child take the dose of KALYDECO as prescribed with fat-containing food as soon as possible.

If your child misses a dose and it is more than 6 hours after the time he or she usually takes it, have your child skip that dose only and take the next dose with fat-containing food when he or she usually takes it. Do not take 2 doses at the same time to make up for a missed dose.

What is KALYDECO® (ivacaftor)?

KALYDECO is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients age 2 years and older who have one of the following mutations in their CF gene: G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N, or S549R.

KALYDECO is used for the treatment of CF in patients age 2 years and older who have an R117H mutation in their CF gene.

KALYDECO is not for use in people with CF due to other mutations in the CF gene. KALYDECO is not effective in patients with CF with two copies of the F508del mutation (F508del/F508del) in the CF gene.

It is not known if KALYDECO is safe and effective in children under 2 years of age.

Important Safety Information

Who should not take KALYDECO?

Do not take KALYDECO if you take certain medicines or herbal supplements such as: the antibiotics rifampin (Rifamate®, Rifater®) or rifabutin (Mycobutin®); seizure medications such as phenobarbital, carbamazepine (Tegretol®, Carbatrol®, Equetro®) or phenytoin (Dilantin®, Phenytek®); or St. John’s wort.

Talk to your doctor before taking KALYDECO if you take any of these medicines or supplements.